The combination oxycodone/naltrexone is indicated for the management of pain severe enough to require daily, around-the-clock, long-term. J Pain. Jun;6(6) Adding ultralow-dose naltrexone to oxycodone enhances and prolongs analgesia: a randomized, controlled trial of Oxytrex. Troxyca ER (oxycodone + naltrexone): For the management of severe pain. New approved drug details including side effects, uses and general information. Subject agrees to refrain from taking opioid medications other than study drug during the study. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. A score of 9 or higher was defined as high risk for aberrant medication- related behavior. Eligibility Criteria. Oxycodone and naltrexone will add to the effects of alcohol and other CNS depressants medicines that can make you drowsy or less alert. Abuse potential study of ALO extended-release oxycodone surrounding sequestered naltrexone compared with immediate-release oxycodone administered orally to nondependent recreational opioid users. Check with your doctor before taking any of these medicines while you are oxycodone naltrexone oxycodone and naltrexone. Monitor for respiratory depression, particularly when initiating or increasing dosage. Daily news summary. If you have been using oxycodone and naltrexone regularly nalhrexone several weeks or longer, do not change your dose or continue reading stop using it without checking with your doctor. Instruct patients to swallow capsules whole. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.